The pyralomicins are a group of antibiotics, reported in 1996 by Takeuchi and co-workers, with unique chemical structures, a benzopyranopyrrole chromophore containing a nitrogen atom which is glycosylated by C7 cyclitols (pyralomicins 1a-1d) or by glucose (pyralomicins 2a-2c). The cyclitol structure in pyralomicins 1a-1d is similar to the valienamine moiety of acarbose and other related compounds, the only difference being the opposite stereochemistry at the C-1ยด position. These antibiotics were isolated from the soil bacterium, Nonomuraea spiralis. Pyralomicins 1a~1d are the only examples of natural products reported thus far having a C7N aminocyclitol act as the glycone attached to a polyketide-derived core structure.
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