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Publications:


Tennessen JA, Govindarajulu R, Liston A, Ashman TL (2013) Targeted sequence capture provides insight into genome structure and genetics of male sterility in a gynodioecious diploid strawberry, Fragaria vesca ssp. bracteata (Rosaceae). G3 3:1341-1351


Christie MR, Tennessen JA, Blouin MS (2013) Bayesian parentage analysis with systematic accountability of genotyping error, missing data, and false matching. Bioinformatics 29:725-732


Tennessen JA*, Bigham AW*, O’Connor TD*, Fu W, Kenny EE, Gravel S, McGee S, Do R, Liu X, Jun G, Kang HM, Jordan D, Leal SM, Gabriel S, Rieder MJ, Abecasis G, Altshuler D, Nickerson DA, Boerwinkle E, Sunyaev S, Bustamante CD, Bamshad MJ, Akey JM, Broad GO, Seattle GO, NHLBI Exome Sequencing Project (2012) Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science 337:64-69


Tennessen JA, O’Connor TD, Bamshad MJ, Akey JM (2011) The promise and limitations of population exomics for human evolution studies. Genome Biology 12:127


Tennessen JA, Akey JM (2011) Parallel adaptive divergence among geographically diverse human populations. PLoS Genetics 7:e1002127


Tennessen JA, Madeoy J, Akey JM (2010) Signatures of positive selection apparent in a small sample of human exomes. Genome Research 20:1327-1334


Tennessen JA, Blouin MS (2010) A revised leopard frog phylogeny allows a more detailed examination of adaptive evolution at ranatuerin-2 antimicrobial peptide loci. Immunogenetics 62:333-343


Tennessen JA, Woodhams DC, Chaurand P, Reinert LK, Billheimer D, Shyr Y, Caprioli RM, Blouin MS, Rollins-Smith LA (2009) Variations in the expressed antimicrobial peptide repertoire of northern leopard frog (Rana pipiens) populations suggest intraspecies differences in resistance to pathogens. Developmental & Comparative Immunology 33:1247-1257


Tennessen JA, Blouin MS (2008) Balancing selection at a frog antimicrobial peptide locus: fluctuating immune effector alleles? Molecular Biology and Evolution 25:2669–2680


Tennessen JA (2008) Positive selection drives a correlation between non-synonymous/synonymous divergence and functional divergence. Bioinformatics 24:1421-1425


Tennessen JA, Zamudio KR (2008) Genetic differentiation among mountain island populations of the striped plateau lizard, Sceloporus virgatus (Squamata: Phrynosomatidae). Copeia 2008:558-564


Miranda RR, Tennessen JA, Blouin MS, Rabelo EM (2008) Mitochondrial DNA variation of the dog hookworm Ancylostoma caninum in Brazilian populations. Veterinary Parasitology 151:61-67


Tennessen JA, Blouin MS (2007) Selection for antimicrobial peptide diversity in frogs leads to gene duplication and low allelic variation. Journal of Molecular Evolution 65:605-615


Tennessen JA (2005) Molecular evolution of animal antimicrobial peptides: widespread moderate positive selection. Journal of Evolutionary Biology 18:1387-1394


Tennessen JA (2005) Enhanced synonymous site divergence in positively selected vertebrate antimicrobial peptide genes. Journal of Molecular Evolution 61:445-455


Tennessen JA, Zamudio KR (2003) Early-male reproductive advantage, multiple paternity, and sperm storage in an amphibian aggregate breeder. Molecular Ecology 12:1567-1576

jacob.tennessen (AT) gmail (DOT) com

Curriculum Vitae

I am interested in the effects of natural selection on patterns of molecular genetic diversity within and between species. Major former and ongoing research projects of mine include:


Antimicrobial peptide evolution in leopard frogs

Genomic scans for local adaptation in human populations

Genetic basis of trematode parasite resistance in snails

Evolution of sex determination in strawberries

Others

Jacob A Tennessen, PhD

Evolutionary Geneticist

Oregon State University

Jacob Tennessen